Effect of Selenium Supplementation on Glucose Homeostasis, Inflammation and Oxidative Stress in Pregnant Women With Gestational Diabetes

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Benefits of Selenium Supplementation in Pregnant Women With Gestational Diabetes

A randomised, double-blind, placebo-controlled clinical trial published in the journal Nutrition investigated the effect of selenium supplementation on the metabolic profile of pregnant women with gestational diabetes mellitus (GDM) who were not on oral hypoglycaemic agents (OHAs).

The study included 70 pregnant women (18–40 years old) primigravida with GDM at 24–28 weeks of gestation who were randomised in a 1:1 ratio to selenium supplements (200 µg) or placebo for six weeks. At the study baseline and six weeks after intervention, the height and weight of the pregnant women were measured and fasting blood samples were obtained. Pre-pregnancy height and weight measurements as well as newborns’ height, weight and head circumference measurements were obtained from hospital records.

Pregnant women who received selenium supplementation had significantly lower levels of fasting plasma glucose, serum insulin, and homeostasis model of assessment-insulin resistance and significantly higher levels of quantitative insulin sensitivity check index compared to the placebo group. Lower levels of serum high sensitivity C-reactive protein and plasma malondialdehyde and higher levels of plasma glutathione were also observed with selenium supplementation. However, selenium supplementation had no significant effect on homeostatic model assessment-beta cell function, lipid profiles, plasma nitric oxide and total antioxidant capacity concentrations.

This study concluded that selenium supplementation in pregnant women with GDM is positively linked with improved glucose homeostasis and oxidative stress as well as reduced inflammation. Lipid profiles and plasma nitric oxide levels were not significantly impacted by selenium supplementation. Future trials are required to establish appropriate selenium dosage for pregnant women with GDM.

News source: Asemi Z, Jamilian M, Mesdaghinia E, et al. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Nutrition. 2015;31(10):1235–1242.