Effect of Probiotics on Duration of Diarrhoea, Length of Emergency Care and Hospital Stay in Children With Acute Diarrhoea

schedule 2 min read

Benefits of Probiotics in Children With Acute Diarrhoea

A clinical trial published in the journal Beneficial Microbes assessed the effect of Saccharomyces boulardii CNCM I-745 on the duration of diarrhoea in children from three clinical admission settings (hospitalised children, those requiring emergency care unit [ECU] follow-up and those in outpatient settings).

The prospective, single-blind, multicenter, randomised controlled study included 363 children aged 3–60 months who had acute watery diarrhoea that lasted 12–72 hours. The children were randomised into the probiotic or control group. The probiotic group received oral lyophilised S. boulardii CNCM I-745 (250 mg twice-daily, 5×109 colony forming units/250 mg sachet) in addition to oral rehydration solution (ORS) and/or intravenous therapy for five days. The control group received ORS and/or intravenous therapy. The duration of diarrhoea (time in hours), from admission to cessation of diarrhoea (present even after five days), was the primary outcome evaluated.

In the whole study group, the duration of diarrhoea was about 24 hours shorter in the intervention group (75.4±33.1 hours) compared to the control group (99.8±32.5 hours). The effect of S. boulardii was observed after 48 hours of intervention. Furthermore, after 72 hours, watery diarrhoea was observed only in 27.3% children who received S. boulardii compared to 48.5% children in the control group. Adverse effects related to probiotic use were not reported. In the outpatient setting (n=92), the duration of diarrhoea was shorter in the intervention group (58.9±15.3 hours) compared to the control group (88.0±19.1 hours). After 72 hours, only 2.1% children in the intervention group had watery diarrhoea compared to 47% children in the control group. In ECU follow-up, the length of ECU stay was reduced in children receiving S. boulardii compared to the control group (1.20±0.4 versus 2.0±0.3 days.

The study concluded that S. boulardii was beneficial in shortening the duration of diarrhoea as well as reducing the length of ECU and hospital stay in children with acute infectious diarrhoea.

News source: Dinleyici EC, Kara A, Dalgic N, et al. Saccharomyces boulardii CNCM I-745 reduces the duration of diarrhoea, length of emergency care and hospital stay in children with acute diarrhoea. Benef Microbes. 2015;6(4):415–421.