Association Between Certain Hydrolysate Formulas and Allergic Manifestation in Children at High Risk of Allergic Diseases

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Preventive Effects of Early Hydrolysed Formula Intervention on Allergy Development in Children at High Risk of Allergy

A follow-up study published in the journal Allergy assessed the long-term association between the early use of certain hydrolysed formulas and the occurrence of asthma, allergic rhinitis (AR) and eczema as well as lung function and sensitisation up to adolescence.

A total of 2,252 children from the German Infant Nutritional Intervention (GINI) study who were at high risk of allergy were invited for this 15-year follow-up examination (2011–2013). The children were randomly allocated to receive partial whey hydrolysate (pHF-W), extensive whey hydrolysate (eHF-W), extensive casein hydrolysate (eHF-C) or standard cow’s milk formula (CMF) in the first four months of life. Skin inspection, anthropometric measurements, blood tests for specific immunoglobulin E (IgE) and spirometric lung-function measurements were conducted in children. Outcome measures such as the cumulative incidence of asthma, AR, and eczema up to 15 years of age and the period prevalence between 11 and 15 years of age of the same were evaluated.

The prevalence of asthma between 11 and 15 years was low in the eHF-C group compared to the CMF group. Furthermore, the cumulative incidence of AR was significantly low in the eHF-C group and the prevalence of AR was significantly low in the pHF-W and eHF-C groups between 11 and 15 years. Similarly, the cumulative incidence and the prevalence of eczema between 11 and 15 years were low in the pHF-W and eHF-C groups. However, in the pHF-W group, the reduction in the prevalence of eczema was not significant. There was no significant effect of eHF-W formula on any manifestations or of any formula on sensitization.

This study indicated that, in children who were at high risk for allergic diseases, eHF-C and pHF-W formulas had a preventive effect on asthma, allergic rhinitis and eczema, which sustained until adolescence without the existence of a rebound phenomenon. Furthermore, these formulas did not have an influence on IgE sensitization.

News source: Von Berg A, Filipiak-Pittroff B, Schulz H, et al. Allergic manifestation 15 years after early intervention with hydrolyzed formulas – The GINI Study. Allergy. 2016;71(2):210–219.